What Is SAMe? SAMe (S-Adenosyl-Methionine) was first discovered in 1952 and has been commercially available in Europe since the 1970's. SAMe is an important compound that occurs in every living cell and takes part in several biological reactions in the human body. The important physiological results of these reactions are the manufacture of joint cartilage and the maintenance of neural cell membrane function. SAMe has been studied extensively and has been clinically found to promote and support: Joint Health, Mobility and Joint Comfort* Mood and Emotional Well-being* Sources of SAMe Although SAMe is present in all living organisms, signficant amounts of the substance are not readily available through foods. SAMe is processed from yeast, and then integrated into a stable compound. The resulting compound is then put into a specifically formulated and enteric coated tablet to further enhance stability, provide release of SAMe in the intestinal tract where it is best absorbed, and increase ease of swallowing. The end result of this is the stable and bio-available form of SAMe that Baywood has made available for you. Our product is guaranteed to deliver SAMe in the amount on the label. Safety One of the advantages of SAMe over other compounds is its remarkable safety profile. In clinical studies, orally administered SAMe was typically compared against other compounds or placebo for benefits. SAMe was well tolerated and generally demonstrated an incidence of side effects lower than other compounds and similar to and sometimes lower than the placebo. Suggested Use For optimal absorption into the body, the best time to take SAMe is on an empty stomach at least 30 minutes before a meal. To support and promote joint health, mobility and joint comfort, take 2 tablets twice a day. Clinical studies indicate that benefits may be evident in the first two weeks of supplementation and may continue for a prolonged period of time.* For optimal mood and emotional well-being, take 2 tablets in the morning and 2 tablets in the afternoon. Taking SAMe at bedtime may interfere with a good night's rest. Clinical studies indicate that benefits may be evident within one week of supplementation. If benefits are not achieved in two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works best for you, gradually increase the number of tablets, up to 8 tablets a day, until benefits are achieved.* SAMe can be used regardless of the number of benefits that are being sought. *These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure or prevent any disease. Available in: 20, 30 and 60 Count